The information flow from DNA to RNA to Protein, or in some cases, directly from RNA to Protein lays on the foundation of the sequence–structure–function paradigm that underpins all living systems. Genetic sequences/codes are transcribed into RNA, which then translates this code to synthesize proteins. These proteins fold into specific three-dimensional structures, enabling them to perform diverse cellular functions that sustain and regulate the dynamic nature of life.

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By mapping RNA folds and RNA–protein interactions, our work strives to decode the strategic mechanisms that viruses employ to evade the immune system, enhance their survival, and often evolve into highly transmissible and virulent forms. In a world reshaped by a global pandemic, these questions have become more urgent than ever. Our primary goal is to deepen the understanding of complex biological regulatory processes involving macromolecules, and how they adapt to diverse environments.

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To address the challenges at this interdisciplinary frontier, we integrate the foundational tools of physical chemistry/chemical physics/biophysical chemistry with predictive frameworks rooted in statistical mechanics.

In requirement of advancing this frontier, we are also committed to developing innovative computational methodologies.​​

                                                                                                                                                                                                                                                                                                                                         –  Dr. Susmita Roy